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Synapsin Nasal Spray

Synapsin Nasal Spray

A novel solution to support neurohealth, one patient at a time

Synapsin Nasal Spray is the latest innovation in neurological health. Synapsin® nasal spray is a patented power blend of ginsenoside Rg3 and Nicotinamide Riboside, along with other ingredients to help in dispersion and solubilization. [34] These ingredients are designed to support healthy neurological and cognitive function by targeting neuroinflammation in patients suffering from brain fog associated with fungal/bacterial infections such as chronic inflammatory response syndrome (CIRS), mold/ biotoxin illness, Alzheimer’s, Traumatic Brain Injury (TBI), and oxidative stress to name a few. [35] Neuroinflammation is inflammation in the tissue of the central nervous system (CNS) which can cause neuronal dysfunction, tissue damage, and eventually cell death. [36] Among other sources, neuroinflammation can be induced by environmental toxins/mold/biotoxin illnesses, autoimmune diseases, neurodegeneration, and brain injury.[37]

Synapsin Nasal Spray is often used in combination with methylcobalamin to support and enhance neural and cognitive function.[38]

Synapsin Nasal Spray is a new product available only by a doctor’s prescription and can be compounded into a nasal spray for easy daily administration. At Forte Rx Compounding Pharmacy, our patient’s safety is our sole priority. We offer the highest quality compounded Synapsin® nasal spray with ingredients sourced from the most trusted suppliers nationwide.

Some of the causes of neuroinflammation are as follows:

  • Fungal/Viral/Bacterial Infections such as CIRS and mold/biotoxin illnesses
  • Environmental Pollution
  • Heavy Metal Toxicity
  • Traumatic Brain Injuries such as sports injuries and concussions
  • Autoimmune conditions
  • Chronic stress, such as executive burnout
  • The aging process, Alzheimer’s and Dementia
Synapsin Nasal Spray is often used in combination with methylcobalamin to support and enhance neural and cognitive function.[39]

Synapsin Nasal Spray is a new product available only by a doctor’s prescription and can be compounded into a nasal spray for easy daily administration. At Forte Rx Compounding Pharmacy, our patient’s safety is our sole priority. We offer the highest quality compounded Synapsin Nasal Spray with ingredients sourced from the most trusted suppliers nationwide.

Synapsin Nasal Spray for Brain Fog and Neuroinflammation induced by Environmental Toxins, CIRS, Mold Toxicity/Biotoxin Illness and Lyme Disease

Exposure to fungal pathogens through mold found in one’s environment has been observed by researchers as a cause of neuroinflammation.[40] Neuroinflammation resulting from mold illness has been linked to symptoms of cognitive impairment such as loss of memory, headaches, and brain fog. [41] Brain fog or brain fatigue is often associated with symptoms of poor memory, mild or chronic mental confusion, and difficulty focusing. [42] Synapsin Nasal Spray aims to promote healthy cognitive function with ingredients that target neuroinflammation. [43]

Synapsin Nasal Spray and Neurodegeneration

Synapses are a core component of the nervous system and the brain in particular. By the time we reach our mid-twenties, our human brain is fully developed. Once it’s completely developed, there is a steady decrease in our brain’s volume and vascularization causing us to decline in functions such as memory, reflexes, verbal fluency, and even decision making.[44] This is often a natural side effect of aging but it can also be exacerbated by chronic stress and conditions often associated with cognitive decline including Alzheimer’s and Dementia. One of the main components of SynapsinⓇ nasal spray is Nicotinamide Riboside, a precursor to NAD+. NAD+ plays a key role in several biological processes including metabolism and DNA repair. [45] Healthy levels of NAD+ in the body begin to decrease with age, causing important mitochondrial and cellular functions to decline. [46]

Synapsin Nasal Spray and Brain Injury

Traumatic Brain Injury (TBI) or a concussion is brain damage that occurs due to sudden and severe external trauma to the brain. [47] TBI is most common among adults and results from injuries related to sports, falls, violence, car accidents, military combat, or electric shock. TBI immediately affects the brain’s ability to function and only leads to further decline after the initial injury. [48] Research shows that TBI patients often suffer from a loss of synapses which creates a risk for dementia later in life. [49] The ingredients of Synapsin Nasal Spray include neuroprotective elements that are designed to support healthy neurological and cognitive function. [50]

What is in Synapsin Nasal Spray?

Ginsenoside Rg3

Ginsenoside Rg3 is a neuroprotective component found naturally in the Panax Meyer Ginseng plant. Panax Ginseng is known for its adaptogenic properties, allowing the body to maintain homeostasis. Ginsenoside is derived from ginseng, a plant commonly used in herbal medicine across Asia and the West. Laboratory studies show that ginsenoside Rg3 helps maintain and preserve the brain’s neuronal structure, particularly benefitting memory function.

Nicotinamide Riboside

Nicotinamide Riboside (NR) is a type of Niacin (Vitamin B3) that is naturally found in yeast and cow’s milk. [53] Studies have found NR to be effective in promoting healthy levels of NAD+ (Nicotinamide adenine dinucleotide) in yeast and cultured human and mammalian cells. [54] Scientists have also found NAD+ to be neuroprotective, meaning it works to protect the brain’s neuronal structure and reduce the death of nerve cells after neuron damage. [55] Loss of NAD+ in the body has been linked to various age-related diseases including cognitive decline and cancer. [56] Studies have found that restoring or maintaining healthy NAD+ production can help promote biological processes important for human health and curb further deterioration of the central nervous system. [57]

Synapsin Nasal Spray can be used for patients with the following conditions:

  • Chronic Inflammatory Response Syndrome (CIRS)
  • Mold/Biotoxin Illnesses
  • Lyme Disease
  • Brain fog
  • Alzheimer’s
  • Dementia
  • Traumatic Brain Injury
  • Chronic Stress
  • Stroke
  • Autism
  • Parkinson’s
  • Diabetes
  • And more per your prescriber’s diagnosis

Please contact our clinical department today at (805) 427-9053 and ask to speak with one of our expert CIRS, mold/biotoxin illness, MCAS, and Lyme Disease clinical pharmacists about SynapsinⓇ Nasal Spray

[34] Importance of Rg3 as an anti-inflammatory in Synapsin

Kim, J. H., Yi, Y. S., Kim, M. Y., & Cho, J. Y. (2017). Role of ginsenosides, the main active components of Panax ginseng, in inflammatory responses and diseases. Journal of ginseng research, 41(4), 435–443. https://doi.org/10.1016/j.jgr.2016.08.004

[35] Joo, S. S., Yoo, Y. M., Ahn, B. W., Nam, S. Y., Kim, Y. B., Hwang, K. W., & Lee, D. I. (2008). Prevention of inflammation-mediated neurotoxicity by Rg3 and its role in microglial activation. Biological and Pharmaceutical Bulletin, 31(7), 1392-1396. http://doi.org/10.1248/bpb.31.1392

[36] DiSabato, D. J., Quan, N., & Godbout, J. P. (2016). Neuroinflammation: the devil is in the details. Journal of neurochemistry, 139 Suppl 2(Suppl 2), 136–153. https://doi.org/10.1111/jnc.13607

[37] Hope J. (2013). A review of the mechanism of injury and treatment approaches for illness resulting from exposure to water-damaged buildings, mold, and mycotoxins. TheScientificWorldJournal, 2013, 767482. https://doi.org/10.1155/2013/767482

[38] Bottoni, Don RPh. “Compounding with Synapsin.” Apothagram-The PCCA Blog (September 2017)

[39] Gröber, Uwe, Klaus Kisters, and Joachim Schmidt. 2013. “Neuroenhancement with Vitamin B12—Underestimated Neurological Significance” Nutrients 5, no. 12: 5031-5045. https://doi.org/10.3390/nu5125031

[40] Empting, L. (2009). Neurologic and neuropsychiatric syndrome features of mold and mycotoxin exposure. Toxicology and Industrial Health, 25(9–10), 577–581. https://doi.org/10.1177/0748233709348393

[41] Gordon, W. A., Cantor, J. B., Johanning, E., Charatz, H. J., Ashman, T. A., Breeze, J. L., … & Abramowitz, S. (2004). Cognitive impairment associated with toxigenic fungal exposure: a replication and extension of previous findings. Applied Neuropsychology, 11(2), 65-74.; Harding, C. F., Pytte, C. L., Page, K. G., Ryberg, K. J., Normand, E., Remigio, G. J., DeStefano, R. A., Morris, D. B., Voronina, J., Lopez, A., Stalbow, L. A., Williams, E. P., & Abreu, N. (2020).

[42] Lucius, Khara. ““Brain Fog”: Exploring a Symptom Commonly Encountered in Clinical Practice.” Alternative and Complementary Therapies 27, no. 1 (2021): 23-30.https://doi.org/10.1089/act.2020.29313.klu

[43]  Joo, S. S., Yoo, Y. M., Ahn, B. W., Nam, S. Y., Kim, Y. B., Hwang, K. W., & Lee, D. I. (2008). Prevention of inflammation-mediated neurotoxicity by Rg3 and its role in microglial activation. Biological and Pharmaceutical Bulletin, 31(7), 1392-1396. http://doi.org/10.1248/bpb.31.1392

[44] Effects of Aging on the Brain – Peters R. (2006). Aging and the brain. Postgraduate medical journal, 82(964), 84–88. https://doi.org/10.1136/pgmj.2005.036665 

[45] Mehmel, M., Jovanović, N., & Spitz, U. (2020). Nicotinamide Riboside-The Current State of Research and Therapeutic Uses. Nutrients, 12(6), 1616. https://doi.org/10.3390/nu12061616

[46]Klimova, N. (2019). Neuroprotective role of nicotinamide adenine dinucleotide precursor in modulation of mitochondrial fragmentation and brain energy metabolism (dissertation). Retrieved from http://hdl.handle.net/10713/9620.

[47] Schimmel, S. J., Acosta, S., & Lozano, D. (2017). Neuroinflammation in traumatic brain injury: A chronic response to an acute injury. Brain circulation, 3(3), 135–142. https://doi.org/10.4103/bc.bc_18_17  

[48] Aimun A B Jamjoom, Jonathan Rhodes, Peter J D Andrews, Seth G N Grant, The synapse in traumatic brain injury, Brain, Volume 144, Issue 1, January 2021, Pages 18–31, https://doi.org/10.1093/brain/awaa321

[49]Aimun A B Jamjoom, Jonathan Rhodes, Peter J D Andrews, Seth G N Grant, The synapse in traumatic brain injury, https://doi.org/10.1093/brain/awaa321

[50] Joo SS, Yoo YM, Ahn BW, Nam SY, Kim YB, Hwang KW, Lee DI. Prevention of inflammation-mediated neurotoxicity by Rg3 and its role in microglial activation. Biol Pharm Bull. 2008 Jul;31(7):1392-6. doi: 10.1248/bpb.31.1392. PMID: 18591781.

[51] Kim, J. H., Yi, Y. S., Kim, M. Y., & Cho, J. Y. (2017). Role of ginsenosides, the main active components of Panax ginseng, in inflammatory responses and diseases. Journal of ginseng research, 41(4), 435–443. https://doi.org/10.1016/j.jgr.2016.08.004 

[52] Bao, H. Y., Zhang, J., Yeo, S. J., Myung, C. S., Kim, H. M., Kim, J. M., . . . Kang, J. S. (2005). Memory enhancing and neuroprotective effects of selected ginsenosides. Archives of Pharmacal Research, 28(3), 335-342.

[53]  Bieganowski, P., & Brenner, C. (2004). Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans. Cell, 117(4), 495-502. Retrieved from http://www.cell.com/cell/pdf/S0092-8674(04)00416-7.pdf  

[54] Mehmel, M., Jovanović, N., & Spitz, U. (2020). Nicotinamide Riboside-The Current State of Research and Therapeutic Uses. Nutrients, 12(6), 1616. https://doi.org/10.3390/nu12061616

[55]  Chi, Y., & Suave, A. A. (2013). Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotection. Current Opinion in Clinical Nutrition and Metabolic Care, 16(6), 657-661. https://doi.org/10.1097/MCO.0b013e32836510c0

[56]  Lautrup, S., Sinclair, D. A., Mattson, M. P., & Fang, E. F. (2019). NAD+ in Brain Aging and Neurodegenerative Disorders. Cell metabolism, 30(4), 630–655. https://doi.org/10.1016/j.cmet.2019.09.001

[57] Covarrubias, A.J., Perrone, R., Grozio, A. et al. NAD+ metabolism and its roles in cellular processes during aging. Nat Rev Mol Cell Biol 22, 119–141 (2021). https://doi.org/10.1038/s41580-020-00313-x